WafeRest^®

Product Information

Circadian rhythm sleep disorders (CRSD) is a family of sleep disorders which affect an individual’s sleep timing. Regardless transient or chronic, CRSDs impact negatively upon a wide range of individuals, including the elderly, shift-workers and jet travellers who move rapidly across various time zones. In addition, several forms of insomnia affect a large population in the community. Both CRSDs and insomnia share a common feature, i.e. the sensitivity to melatonin, a hormone secreted by the pineal gland.¹

REDUCE SLEEP LATENCY

It is common for shift-workers to suffer from sleep disruptions. A chronobiotic is an agent that can regulate the internal body clock’s sleep-wake cycle.
Due to its chronobiotic properties, melatonin is capable of readjusting dissociated circadian rhythms in shift-workers, allowing them to sleep at odd hours.²
Numerous studies have shown that melatonin therapy given 30 minutes prior bedtime in shift-workers has significantly improved their sleep onset latency and sleep efficiency.²

ALLEVIATE JET LAG

When individuals travel to a new time zone, their endogenous circadian rhythms fall out of synchony with the day/night cycle at the traveler’s destination. This state of imbalance in the body’s natural “biological clock” results in jet lag. Some symptoms of jetlag include depressed mood, daytime sleepiness, impaired alertness, insomnia and loss of appetite.³
Supplementation with melatonin may reset the body’s sleep-wake cycle as well as relieving daytime fatigue associated with jet lag, effectively preventing or reducing jet lag. The use of melatonin by air travelers shows promise to prevent phase shifts from jet lag.³

PROMOTE SLEEP

Insomnia is a term referring to both the subjective symptoms of difficulty initiating sleep, frequent night or early morning awakenings and to an underlying disorder. Multiple studies have demonstrated the efficacy of melatonin efficacy in improving and promoting sleep in patients with insomnia.^4,5

OUR PATENTED WAFERIX^® TECHNOLOGY

With our patented WaferiX^® delivery technology, WafeRest^® sublingual wafer allows melatonin to be absorbed into the blood for its use through the mucosal membrane under the tongue. This wafer formulation improves the bioavailability of melatonin in multifolds.

WAFEREST is covered by the following patents and applications: Australia (2010313785), Austria (2493457), Belgium (2493457), Canada (2,777,218), China (ZL201080046185.X), Denmark (2493457), Finland (2493457), France (2493457), Germany (2493457), Hong Kong (HK1175690), India (1323/MUMNP/2012), Indonesia (IDP000036973), Ireland (2493457), Italy (502017000115917), Japan (5777170), Macau (J/3050), Malaysia (MY-150626-A), Netherlands (2493457), New Zealand (599594), Norway (2493457), Poland (2493457), South Korea (10-1612073), Singapore (174465), Spain (2493457), Sweden (2493457), Switzerland (2493457), Thailand (1201001664), Turkey (2493457), United Kingdom (2493457), USA (13/504,309), Vietnam (21037).

Ingredients

Serving Size: 1-2 wafers
Servings Per Carton: Up to 30
Amount Per Wafer:

Directions

How to use

For best results, take 1-2 wafers at least 20 minutes prior to bedtime. When travelling, take 1-2 wafers before expected bedtime in the new time zone and as required or as recommended by your physician.

Storage

Store in cool, dry place. Keep out of reach of children. Use only if carton is sealed.

Warnings

This product works fast to promote and support sound sleep. It may help combat the debilitating effects of jet-lag. It is not meant for prolonged consumption. May cause drowsiness. Do not drive or operate heavy machinery following consumption. This product is not intended to treat, cure, or prevent any diseases. Do not take WafeRest^® if you are pregnant, breastfeeding or trying to conceive, or under 18 years of age. If you have any medical conditions, please consult your physician prior to use.

Science

1. Turek, F. and Gillette M. (2004). Melatonin, Sleep, and Circadian Rhythms: Rationale for Development of Specific Melatonin Agonists. Sleep Medicine, [Online] 5(6), pp.523-532. Available at: http://www.sciencedirect.com/science/article/pii/S1389945704001315. [Accessed 20 Oct. 2017].
2. Sadeghniiat-Haghighi K, Bahrami H, Aminian O, Meysami A, Khajeh-Mehrizi A. Melatonin therapy in shift workers with difficulty falling asleep: A randomized, double-blind, placebo-controlled crossover field study. Work. 2016;55(1):225-230.
3. Costello, R., Lentino, C., Boyd, C., O’Connell, M., Crawford, C., Sprengel, M. and Deuster, P. (2014). The Effectiveness of Melatonin for Promoting Healthy Sleep: A Rapid Evidence Assessment of the Literature. Nutrition Journal, [Online] 13(1). Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273450/. [Accessed 20 Oct. 2017].
4. Buscemi N, Vandermeer B, Pandya R, Hooton N, Tjosvold L, Hartling L, Baker G, Vohra S, Klassen T. Melatonin for Treatment of Sleep Disorders. Evidence Report/Technology Assessment (Summary). 2004;(108):1-7
5. Xie, Z., Chen, F., Li, W., Geng, X., Li, C., Meng, X., Feng, Y., Liu, W. and Yu, F. (2017). A Review of Sleep Disorders and Melatonin. [Online] Taylor and Francis Online. Available at: http://www.tandfonline.com/doi/full/10.1080/01616412.2017.1315864. [Accessed 20 Oct. 2017].

FAQ

Who is WafeRest^® suitable for?

WafeRest^® is suitable for men and women:
– whose sleep-wake cycle has been disrupted due to jet lag or irregular work shifts
– who have difficulty falling asleep

What has melatonin been used for?

Primary insomnia, jet lag, anxiety, occasional sleep disturbances, paediatric patients in hospitals.

How fast does WafeRest^® take effect?

~15 to 20 mins after resting in a quiet darkened room.

What are the benefits of using synthetic melatonin in WafeRest^® over natural animal based melatonin?

Synthetic melatonin is unlikely to be contaminated with traces of unwanted proteins.

Can I take WafeRest^® with other medication?

If you are taking medications or have a medical condition, consult a physician or pharmacist before using this product.

Can children/elderly take WafeRest^®?

Melatonin can be used in children and the elderly, under the recommendation of a healthcare professional. There have been studies around melatonin use in children and the elderly.