MelaniX^®

Product Information

In Australia, nonmelanoma skin cancers are four times as common as all other cancers combined. Nonmelanoma skin cancers (NMSC), mainly basal cell and squamous cell carcinomas are the most prevalent cancers in the white population due to exposure to ultraviolet (UV) radiation¹. The increasing incidence of nonmelanoma skin cancer worldwide highlights the need for additional preventive measures¹. There is growing evidence that oral nicotinamide and carotenoids can protect the skin from the detrimental effects such as erythema and skin damage caused by solar UV radiation^2,3. Zinc has also been identified for various physiological functions, including wound healing, survival and anti-inflammatory effects.

Repair damaged DNA

Poly-ADP-ribose polymerase-1 (PARP-1) is an enzyme that detects DNA damage and initiates DNA repair. For PARP-1 to exert its effect, it requires NAD+ as its sole substrate. Nicotinamide, which is a precursor of NAD+ prevents damaged DNA replication and the initiation of DNA repair to protect cellular integrity and improve skin health⁴.

Support healthy skin & wound healing

Nicotinamide has anti-inflammatory, anti-oxidant, barrier repair and protective effects. Its ability to prevent depletion of cellular energy, repair DNA, inhibit integration of proviral DNA and suppress production of inflammatory factors results in reduction in cases of non melanoma skin cancers, actinic keratosis, symptoms of eczema, acne, psoriasis and other skin conditions³. Zinc is a naturally occurring mineral and is present in a number of zinc-dependent metallo-enzymes in the skin, that’s involved in wound repair. It has also been shown to be effective in improving the rate of wound healing, skin repair, maintenance, defense and treating inflammatory skin conditions⁵.

Prevent incidence of UV-induced skin conditions

b- carotene that is found in tomato extracts has strong antioxidant properties that contribute to its photoprotective effects of solar radiation-induced health damage from UVA and B radiation. It does so by inhibiting UVA1 expression of the radiation inducible genes Hoq, ICAM1, and MMP1 ². As a precursor of NAD+, nicotinamide is able to prevent UV-induced depletion of ATP in skin cells, accelerating energy-dependent DNA repair processes. It’s ability to suppress immunosuppression caused by UV radiation and preventing oxidative stress caused from UV rays protect the skin from nonmelanoma skin cancer ⁴.

Ingredients

Serving Size: 2 tablets
Servings Per Container: 60
Amount Per Tablet:

Directions

How to use

Take 2 tablets daily after meals or as recommended by your physician. If symptoms persist consult your healthcare practitioner.

Storage

Keep out of reach of children. Store below 25^oC in cool dry place. Use only if bottle is sealed.

Precautions

Do not take MelaniX^® if you are pregnant, breastfeeding, trying to conceive or under 18 years of age.
If you have any medical conditions, please consult your physician prior to use.

Science

1. Chen AC, Martin AJ, Choy B, et al. A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. N Engl J Med 2015; 373: 1618-1626.
2. Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J. Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study. Br J Dermatol. 2017 May;176(5):1231-1240.
3. Bains P, Kaur M, Kaur J, Sharma S. Nicotinamide: Mechanism of action and indications in dermatology. Indian J Dermatol Venereol Leprol. 2018;84(2):234-237.
4. Forbat E, Al-Niaimi F, Ali FR. Use of nicotinamide in dermatology. Clin Exp Dermatol. 2017 Mar;42(2):137-144.
5. Schwartz JR, Marsh RG, Draelos ZD. Zinc and skin health: overview of physiology and pharmacology. Dermatol Surg. 2005 Jul;31(7 Pt 2):837-47; discussion 847.

FAQ

Should I take MelaniX^® long term?

Entity’s MelaniX^® has been specifically formulated to support skin health, wound healing, DNA repair and to prevent solar keratosis from UV damage. For best results, it should be taken everyday.

Can I take MelaniX^® with LumeniX^® for my skin?

Yes, they work on different pathways, so taking both could be beneficial for the skin.

Why has zinc been added to MelaniX^®?

The skin has the third highest abundance of zinc in the body, and zinc supplementation repairs skin cells and restores skin health.