SL-NAD+
Single Pack
USD119

Your life and vitality,
It all starts with NAD

Found in every human cell, NAD plays a critical role in literally hundreds of your body’s fundamental processes.


Shop Now
 
 

Functions of NAD

NAD plays a fundamental role in almost every cellular process, making it vital for optimal body function and should be considered in any approach aimed at combating aging.

 

When our NAD levels are low,
we don't function optimally


As we age, our natural NAD levels decline

By age 50, NAD+ levels are halved. Why? Firstly, as DNA damage accumulates over time, PARP activity goes into overdrive to repair the damage, consuming more and more NAD.

Secondly, as we age, we have more chronic inflammation, which leads to an increase in immune cells with a surface protein called CD38. CD38 devours NAD to produce cellular signaling molecules consuming up to 100 NAD molecules at a time. All of this results in lower and lower NAD levels, largely due to what we eat and how we live.

Lower NAD levels contributes to aging. We age because our cells age

The cumulative health of each of our 30 trillion cells determine how biologically old we are.

If our cells are not functioning optimally, neither do we. Aging is experienced through fatigue, weakness, increased inflammation, slower recovery from illnesses, memory decline, joint and muscle pain, joint stiffness, slower movement, compromised immune function, increased susceptibility to infections and age-associated diseases.

 

Boost NAD to combat aging where it starts—in your cells.

 
The challenge of NAD delivery

Scientific research supports NAD supplementation as a general anti-aging strategy. But for years, unlocking the full potential of NAD posed challenges as NAD could not be easily absorbed.

NAD is too unstable to be delivered orally and breaks down in the digestive tract when swallowed.

Years of research, countless trials, and a game-changing outcome, SL-NAD+

Our R&D team, with deep-rooted expertise in pharmaceutical drug delivery, took on the challenge of NAD+ delivery. After extensive research and rigorous testing, we achieved a breakthrough: SL-NAD+.

Powered by our patented WaferiX technology, SL-NAD+ is pure NAD+ in a stabilized, nanoparticle form, crafted into a convenient wafer through a precise freezedrying process.

In 2024, a human trial demonstrated significant NAD+ absorption after taking SL-NAD+, with participants showing significantly elevated blood NAD+ levels by 59% after two weeks and 76% after six weeks of taking SL-NAD+. Participants also reported improvements in energy, mood, sleep quality, mental clarity, and/or physical strength, with the product proving safe and well-tolerated.

The Gold Standard of
NAD supplementation

SL-NAD+ is the new easy-to-use gold standard for boosting NAD+ levels.


Professor Brian Kennedy

Scientific Advisor, Entity Health

Distinguished Professor of Biochemistry, Director of Centre for Healthy Longevity, National University of Singapore Yong Loo Lin School of Medicine, Singapore

 
References
  1. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471.
  2. Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism. 2018; 27:529-547.
  3. Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443. PMID: 18429699.
  4. Lin SJ, Guarente L. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol. 2003 Apr;15(2):241-6.
 
  • NAD powers DNA repair through PARP activation

    Another critical function that NAD powers is DNA repair. Every day, our DNA faces constant damage from what we eat, how we live, and exposure to harmful toxins and even UV radiation from the sun. If left unrepaired, it can lead to mutations, malfunctions and even dreaded diseases like cancer. To combat this, the body uses PARP proteins to repair the damaged DNA.

    PARPs need NAD to function.

  • NAD regulates the genes of aging and is known as the molecule of youth

    NAD is critical for the function of sirtuins, the “longevity proteins”. Sirtuins are a family of seven proteins linked to longevity and considered pivotal regulators of lifespan and healthspan through their involvement in fundamental biological processes.

    It plays a crucial role in the Krebs cycle, which is a series of biochemical reactions to release energy from nutrients like carbohydarates, fats and proteins. This takes place in the mitochondria, often referred to as the “powerhouse” of our cells. This cycle is essential for energy production, generating ATP, the primary energy currency of the cell.

    ATP is vital for maintaining cellular functions, facilitating biological processes, and supporting critical muscle functions, including breathing and the heartbeat.

    Sirtuins contribute to longevity by:

    • • Enhancing DNA repair and reducing damage, promoting cellular health
    • • Regulating metabolism, especially in response to caloric restriction, which is known to extend lifespan
    • • Reducing inflammation, thereby improving health and potentially extending lifespan
  • NAD powers the mitochondria, the powerhouse of the cells

    Naturally produced in the body, NAD+ is the oxidized form of nicotinamide adenine dinucleotide. It is a coenzyme found in all living cells and exists in the body as a redox pair.

    NAD is a molecule involved in critical biological processes such as cellular energy and cellular repair that make life possible.

  • Glutathione supports liver detoxification and health

    Glutathione is essential for liver health. The liver is constantly exposed to toxins and undergoes metabolic processes that generate harmful free radicals. Glutathione’s antioxidant properties protect liver cells from damage and supports the liver’s detoxification processes.

    In addition, glutathione regulates liver inflammation. By reducing chronic inflammation, it lowers the risk of liver diseases, such as fatty liver disease, and supports healthy liver function.

    Glutathione also aids in fat processing and elimination by supporting bile production, which is necessary for fat digestion and absorption. Through enhanced fat metabolism, glutathione further promotes overall liver health.

  • Glutathione enhances immunity and fights viral infections

    Glutathione is essential for immune health, supporting the function of T cells, B cells, and macrophages. Some studies also suggest that it may help disrupt the replication of certain viruses.

    As we age, glutathione also helps address skin discoloration by inhibiting tyrosinase, the enzyme responsible for melanin production, which reduces dark spots and uneven pigmentation. It also offers protection against UV radiation, helping to prevent photoaging.

  • Glutathione protects against premature skin aging

    Free radicals generated by environmental factors such as UV radiation, pollution, and toxins damage skin cells, leading to premature aging, wrinkles, and other skin problems.

    By neutralizing free radicals, glutathione protects the skin’s delicate balance and prevents premature aging.

    Glutathione plays a crucial role in managing inflammation, which is key in skin conditions such as acne, eczema, and psoriasis. By modulating the inflammatory response, it reduces redness, irritation, and other symptoms while supporting a healthy skin barrier for a youthful, radiant complexion. This contributes to improved skin texture, tone, and an overall vibrant appearance.

  • Dr Brian Kennedy, PhD

    Scientific Advisor

    Dr. Kennedy is a Distinguished Professor in the National University of Singapore (NUS) Yong Loo Lin School of Medicine, Departments of Biochemistry and Physiology. He is the Director of the Healthy Longevity Translational Research Programme in NUS and Director of the Centre For Healthy Longevity, National University Health System (NUHS). Prior to this, he was the President and CEO of the Buck Institute for Research on Aging and he maintained a professorship there through 2020. He served as the Co-Editor-In-Chief at the journal Aging Cell from 2011 to 2021.

    Dr. Kennedy is widely recognized for his contributions in the biology of aging and as a visionary committed to translating research discoveries into new ways to delay, detect and prevent human aging and its associated diseases. With a plethora of widely-cited research papers on aging and longevity under his belt, he is regarded as an expert in the science of gerontology.

  • Dr Stephen Lim

    Chief Pharmacist

    Dr Stephen Lim is an Adjunct Professor in the School of Pharmacy at Curtin University and has more than 35 years experience in the hospital and commercial pharmacy sectors. His interest is mainly in research, drug safety and drug delivery, especially in the area of needle-less systems.

    Dr Lim is also an expert in drug storage and extending the shelf-life of medication. He completed his Master thesis by looking at drug stability in the frozen state and has shown that intranasal fentanyl delivery is as effective as intravenous fentanyl.

    Dr Lim obtained a Bachelor of Pharmacy (with distinctions), a Master of Pharmacy and a Ph.D. in Pharmacy in novel, drug delivery system from Curtin University.

  • Dr Iain Cook

    Chief Scientist

    Dr Iain Cook has more than 30 years of experience in the analysis of complex pharmaceutical and biological samples, with a background in pharmaceutical, veterinary, industrial and agrichemical industries.

    Prior to his appointment as Chief Scientist, Dr Cook was the director of Chemical Analysis Pty Ltd. He also served as analytical chemist at ICI/Orica, where he specialised in nuclear magnetic resonance and led its Spectroscopy Group (NMR/FTIR/SEM-EDXA/NIR), and at PROBE Analytical thereafter.

    Dr Cook obtained his Doctor of Philosophy in Nuclear Magnetic Resonance and Synthetic Organic Chemistry from La Trobe University.

  • Dr Janakan Krishnarajah

    Chief Medical Officer

    Dr Janakan Krishnarajah is the Chief Operating and Medical Officer of iX Biopharma, parent company of Entity Health. In his capacity, he is responsible for iX Biopharma’s pharmaceutical and nutraceutical product development, including the design and implementation of clinical trial programmes. He also oversees the operations of the Group’s wholly owned certified GMP manufacturing facility in Australia.

    Dr Krishnarajah was formerly the CEO and Medical Director of Linear Clinical Research Ltd, a leading Australian early phase clinical trials facility. He has extensive experience in phase I-IV clinical trials and has acted as Principal or Co-Investigator in over 100 Phase I/II clinical trials.

    Dr. Krishnarajah graduated with a Bachelor of Medicine, Bachelor of Surgery (Hons) from The University of Western Australia. He is a Fellow of the Royal Australasian College of Physicians and Specialist in Clinical Pharmacology and Internal Medicine previously having worked as a Consultant Physician in Western Australia. He is also a member of Longevity Docs, an exclusive community dedicated to physicians pioneering precision and evidence-based practices in longevity medicine.