Functions of NAD
NAD plays a fundamental role in almost every cellular process, making it vital for optimal body function and should be considered in any approach aimed at combating aging.


NAD powers the mitochondria, the powerhouse of the cells
Naturally produced in the body, NAD+ is the oxidized form of nicotinamide adenine dinucleotide. It is a coenzyme found in all living cells and exists in the body as a redox pair.
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NAD regulates the genes of aging and is known as the molecule of youth
NAD is critical for the function of sirtuins, the “longevity proteins”. Sirtuins are a family of seven proteins linked to longevity and considered pivotal regulators of lifespan.
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NAD powers DNA repair through PARP activation
Another critical function that NAD powers is DNA repair. Every day, our DNA faces constant damage from what we eat, how we live, and exposure to harmful toxins and even UV radiation from the sun.
PARPs need NAD to function.
Learn moreWhen our NAD levels are low,
we don't function optimally

As we age, our natural NAD levels decline
By age 50, NAD+ levels are halved. Why? Firstly, as DNA damage accumulates over time, PARP activity goes into overdrive to repair the damage, consuming more and more NAD.
Secondly, as we age, we have more chronic inflammation, which leads to an increase in immune cells with a surface protein called CD38. CD38 devours NAD to produce cellular signaling molecules consuming up to 100 NAD molecules at a time. All of this results in lower and lower NAD levels, largely due to what we eat and how we live.
Lower NAD levels contributes to aging. We age because our cells age
The cumulative health of each of our 30 trillion cells determine how biologically old we are.
If our cells are not functioning optimally, neither do we. Aging is experienced through fatigue, weakness, increased inflammation, slower recovery from illnesses, memory decline, joint and muscle pain, joint stiffness, slower movement, compromised immune function, increased susceptibility to infections and age-associated diseases.
Boost NAD to combat aging where it starts—in your cells.
The challenge of NAD delivery
Scientific research supports NAD supplementation as a general anti-aging strategy. But for years, unlocking the full potential of NAD posed challenges as NAD could not be easily absorbed.
NAD is too unstable to be delivered orally and breaks down in the digestive tract when swallowed.
Years of research, countless trials, and a game-changing outcome, SL-NAD+
Our R&D team, with deep-rooted expertise in pharmaceutical drug delivery, took on the challenge of NAD+ delivery. After extensive research and rigorous testing, we achieved a breakthrough: SL-NAD+.
Powered by our patented WaferiX technology, SL-NAD+ is pure NAD+ in a stabilized, nanoparticle form, crafted into a convenient wafer through a precise freezedrying process.
In 2024, a human trial demonstrated significant NAD+ absorption after taking SL-NAD+, with participants showing significantly elevated blood NAD+ levels by 59% after two weeks and 76% after six weeks of taking SL-NAD+. Participants also reported improvements in energy, mood, sleep quality, mental clarity, and/or physical strength, with the product proving safe and well-tolerated.
These results were supported by the results of pharmacokinetic studies in rats which demonstrated rapid NAD+ absorption in blood plasma and significant increase in intracellular NAD+ levels.
The studies strongly suggest that NAD+ can be transported in and out of cells directly (NAD+ flux), most probably via connexin 43 hemichannels and other solute carrier channels. This is the first in-vivo study to provide evidence supporting this capability.
The Gold Standard of
NAD supplementation
SL-NAD+ wafers
Bypasses degradation in GI tract
Direct absorption into bloodstream
Contains NAD molecule, No conversion required
NAD immediately available to cells
Non-invasive
Daily, convenient
NAD IV infusion
GI absorption poor
Highly variable due to enzymatic deprivation
Conversion to NAD required in the cells
Conversion variable due to enzyme activity, which declines with age & health
Invasive
Inconvenient
NAD injection
Direct absorption into bloodstream
Consistent, predictable dosing
Contains NAD molecule, no conversion required
NAD immediately available to cells
Invasive
Infrequent high dosing
Inconvenient
SL-NAD+ is the new easy-to-use gold standard for boosting NAD+ levels.

Professor Brian Kennedy
Scientific Advisor, Entity Health
Distinguished Professor of Biochemistry, Director of Centre for Healthy Longevity, National University of Singapore Yong Loo Lin School of Medicine, Singapore
References
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471.
- Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism. 2018; 27:529-547.
- Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443. PMID: 18429699.
- Lin SJ, Guarente L. Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol. 2003 Apr;15(2):241-6.