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Melatonin restores your sleep naturally


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Sleep fuels a longer, healthier life

Sleep is the foundation of health and longevity. Studies show that adults who consistently achieve 7-9 hours of sleep nightly have significantly reduced risks of chronic diseases like cardiovascular conditions and dementia. Sleep also contributes to cellular and immune system health, and high-quality sleep directly supports physical resilience and mental acuity, all of which are essential for a longer, healthier life.

 

Deep sleep repairs your body at the cellular level

Cellular restoration occurs during deep sleep when the body engages in:

  • DNA Repair: Research demonstrates that oxidative damage accumulated during waking hours is repaired during sleep, particularly in cells most susceptible to aging (e.g., neurons and skin cells).
  • Growth Hormone Release: Studies have shown that growth hormone secretion peaks during slow-wave sleep, facilitating tissue repair and maintaining muscle mass.

Immune strength starts with sleep

Studies reveal that individuals who consistently sleep well have:

  • Increased production of cytokines and immune cells to fight infections.
  • Reduced levels of chronic inflammation, which is a major contributor to aging and age-related diseases.

Sleep regulates hormones critical for longevity

Hormonal balance is another crucial benefit of sleep:

  • Cortisol: High-quality sleep lowers cortisol levels, reducing inflammation and oxidative stress—key drivers of aging.
  • Insulin Sensitivity: Research links poor sleep to insulin resistance, while regular, restorative sleep improves glucose metabolism and reduces risks of type 2 diabetes.

Sleep protects against age-related brain decline

Adequate sleep is a natural defense against neurodegenerative diseases. During deep sleep:

  • The lymphatic system removes waste products, including beta-amyloid and tau proteins, which are linked to Alzheimer’s disease.
  • Memory consolidation strengthens neural pathways, preserving cognitive function and reducing the risk of dementia.

Poor sleep reduces lifespan, while good sleep extends it

Consistent restorative sleep is associated with a lower risk of chronic diseases and an improved quality of life.

Sleep deprivation, on the other hand, accelerates biological aging by promoting inflammation, oxidative stress, and metabolic dysfunction.

 

Melatonin aligns and regulates your sleep-wake cycle

 
Disruptions to the circadian rhythm cause sleep issues

Your circadian rhythm is your body’s natural internal clock that regulates the timing of various physiological processes, including sleep, wakefulness, and hormone release. This 24-hour cycle is influenced by external factors like light and darkness.

Melatonin naturally regulates the circadian rhythm

Regardless whether transient or chronic, Circadian rhythm sleep disorders (CRSD) and several forms of insomnia affect a large population in the community.

Melatonin levels rise at night and fall during the day

When taken as a supplement, melatonin helps:
Synchronize circadian rhythms

Acts as a signal to adjust your internal clock to match new schedules or time zones.

Encourage faster sleep onset

Reduces sleep latency by reinforcing your body’s readiness to sleep.

Restore sleep-wake balance

Helps mitigate the effects of circadian misalignment caused by jet lag, shift work, or aging.

 

Melatonin works in harmony with your body

Unlike sedatives, melatonin doesn’t force sleep—it naturally aligns your sleep-wake cycle. This makes it particularly effective for conditions where the timing of sleep is the issue rather than sleep quality itself.

 
Shift work
Working night shifts or irregular hours can lead to“circadian misalignment,” where your sleep-wake cycle doesn’t match your schedule. Melatonin helps realign your body’s clock, improving sleep duration and quality during unconventional hours.
Aging
Melatonin production naturally declines with age, contributing to fragmented sleep patterns and difficulty falling asleep. Supplementing with melatonin helps restore this deficiency, promoting deeper and more restorative sleep.
Artificial Light Exposure
Blue light from screens delays melatonin production, causing difficulty in falling asleep. Melatonin supplementation can counteract this delay, signaling your body to prepare for rest.
Jet Lag
Crossing multiple time zones rapidly desynchronizes your internal clock with the external environment. Melatonin may reset the body's sleep-wake cycle as well as relief daytime fatigue associated with jet lag, effectively preventing or reducing jet lag. The use of melatonin by air travelers shows promise to prevent phase shifts from jet lag.
 
References
  1. Sergio Garbarino et al. Role of sleep deprivation in immune-related disease risk and outcomes. Communications Biology, 2021, 4:1304.
  2. Upasana Mukherjee et al. Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer’s disease in elderly. Ageing Research Reviews, 2024, 100:102457.
  3. V. Cheung et al. The effect of sleep deprivation and disruption on DNA damage and health of doctors. Anaesthesia, 2019, 74:434–440.
  4. E.V. Cauter et al. Physiology of growth hormone secretion during sleep. Journal of Pediatrics, 1996, 128(5 Pt 2):S32–S37.
  5. Luciana Besedovsky et al. Sleep and immune function. Pflugers Archiv - European Journal of Physiology, 2012, 463:121–137.
  6. P.Y. Liu et al. Sleep, testosterone, and cortisol balance in aging men. Reviews in Endocrine and Metabolic Disorders, 2022, 23:1323–1339.
  7. Tae Won Kim et al. The impact of sleep and circadian disturbance on hormones and metabolism. International Journal of Endocrinology, 2015. DOI:10.1155/2015/591729.
  8. M. Yolanda Castano et al. Melatonin improves mood status and quality of life and decreases cortisol levels in fibromyalgia. Biological Research for Nursing, 2019, 21(1):22–29.
  9. Fakhrosadat Fayazi et al. Exploring effects of melatonin supplementation on insulin resistance: An updated systematic review of animal and human studies. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2024, 18:103073.
  10. B. Colombo et al. The protective role of cognitive reserve on sleeping disorders in an aging population: A cross-sectional study. Translational Medicine of Aging, 2023, 7:75–79.
  11. Daniel P. Cardinali. Melatonin: Clinical perspectives in neurodegeneration. Frontiers in Endocrinology, 2019, 10:480.
  12. Zefan Zhang et al. Melatonin: A potential nighttime guardian against Alzheimer’s. Molecular Psychiatry, 2024. DOI:10.1038/s41380-024-02691-6.
  13. Francesco P. Cappuccio et al. Sleep duration and all-cause mortality: A systematic review and meta-analysis of prospective studies. Sleep, 2010, 33(5):585–592.
  14. B.S. McEwan et al. Sleep deprivation and circadian disruption. Sleep Medicine Clinics, 2015, 10(1):1–10.
  15. Benefits of sunlight: A bright spot for human health. Environmental Health Perspectives, 2008, 116(4).
  16. Alina Masters et al. Melatonin, the hormone of darkness: From sleep promotion to Ebola treatment. Brain Disorders Therapy, 2014, 4(1). DOI:10.4172/2168-975X.1000151.
  17. A. Khullar. The role of melatonin in the circadian rhythm sleep-wake cycle. Psychiatric Times, 2012, 29(7).
  18. Virna Margarita Martín Giménez et al. Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases. Frontiers in Aging Neuroscience, 2022, 14:888292.
  19. Diane B. Boivin et al. Disturbance of the circadian system in shift work and its health impact. Journal of Biological Rhythms, 2022, 37(1):3–28.
  20. Konrad Kleszczynski and Tobias W. Fischer. Melatonin and human skin aging. Dermato-Endocrinology, 2012, 4(3):245–252.
  21. Tara Samra et al. Melatonin exerts prominent, differential epidermal and dermal anti-aging properties in aged human eyelid skin ex vivo. International Journal of Molecular Sciences, 2023, 24:15963.
  22. Marcia Ines Silvani et al. The influence of blue light on sleep, performance, and wellbeing in young adults: A systematic review. Frontiers in Physiology, 2022. DOI:10.3389/fphys.2022.943108.
  23. Herxheimer A., Petrie K.J. Melatonin for the prevention and treatment of jet lag: A review. Cochrane Database of Systematic Reviews, 2002, Issue 2, CD001520. DOI:10.1002/14651858.CD001520.
  24. Sylvie Tordjman et al. Melatonin: Pharmacology, functions, and therapeutic benefits. Current Neuropharmacology, 2017, 15:434–443.
  25. Francy Cruz‐Sanabria et al. Optimizing the time and dose of melatonin as a sleep-promoting drug: A systematic review of randomized controlled trials and dose–response meta-analysis. Journal of Pineal Research, 2024, 76:e12985. DOI:10.1111/jpi.12985.
  26. Sulafa T. Alqutub et al. Exogenous melatonin use in university students: A cross-sectional survey. Pharmacy, 2024, 12:41. DOI:10.3390/pharmacy1202004.
 
  • NAD powers DNA repair through PARP activation

    Another critical function that NAD powers is DNA repair. Every day, our DNA faces constant damage from what we eat, how we live, and exposure to harmful toxins and even UV radiation from the sun. If left unrepaired, it can lead to mutations, malfunctions and even dreaded diseases like cancer. To combat this, the body uses PARP proteins to repair the damaged DNA.

    PARPs need NAD to function.

  • NAD regulates the genes of aging and is known as the molecule of youth

    NAD is critical for the function of sirtuins, the “longevity proteins”. Sirtuins are a family of seven proteins linked to longevity and considered pivotal regulators of lifespan and healthspan through their involvement in fundamental biological processes.

    It plays a crucial role in the Krebs cycle, which is a series of biochemical reactions to release energy from nutrients like carbohydarates, fats and proteins. This takes place in the mitochondria, often referred to as the “powerhouse” of our cells. This cycle is essential for energy production, generating ATP, the primary energy currency of the cell.

    ATP is vital for maintaining cellular functions, facilitating biological processes, and supporting critical muscle functions, including breathing and the heartbeat.

    Sirtuins contribute to longevity by:

    • • Enhancing DNA repair and reducing damage, promoting cellular health
    • • Regulating metabolism, especially in response to caloric restriction, which is known to extend lifespan
    • • Reducing inflammation, thereby improving health and potentially extending lifespan
  • NAD powers the mitochondria, the powerhouse of the cells

    Naturally produced in the body, NAD+ is the oxidized form of nicotinamide adenine dinucleotide. It is a coenzyme found in all living cells and exists in the body as a redox pair.

    NAD is a molecule involved in critical biological processes such as cellular energy and cellular repair that make life possible.

  • Glutathione supports liver detoxification and health

    Glutathione is essential for liver health. The liver is constantly exposed to toxins and undergoes metabolic processes that generate harmful free radicals. Glutathione’s antioxidant properties protect liver cells from damage and supports the liver’s detoxification processes.

    In addition, glutathione regulates liver inflammation. By reducing chronic inflammation, it lowers the risk of liver diseases, such as fatty liver disease, and supports healthy liver function.

    Glutathione also aids in fat processing and elimination by supporting bile production, which is necessary for fat digestion and absorption. Through enhanced fat metabolism, glutathione further promotes overall liver health.

  • Glutathione enhances immunity and fights viral infections

    Glutathione is essential for immune health, supporting the function of T cells, B cells, and macrophages. Some studies also suggest that it may help disrupt the replication of certain viruses.

    As we age, glutathione also helps address skin discoloration by inhibiting tyrosinase, the enzyme responsible for melanin production, which reduces dark spots and uneven pigmentation. It also offers protection against UV radiation, helping to prevent photoaging.

  • Glutathione protects against premature skin aging

    Free radicals generated by environmental factors such as UV radiation, pollution, and toxins damage skin cells, leading to premature aging, wrinkles, and other skin problems.

    By neutralizing free radicals, glutathione protects the skin’s delicate balance and prevents premature aging.

    Glutathione plays a crucial role in managing inflammation, which is key in skin conditions such as acne, eczema, and psoriasis. By modulating the inflammatory response, it reduces redness, irritation, and other symptoms while supporting a healthy skin barrier for a youthful, radiant complexion. This contributes to improved skin texture, tone, and an overall vibrant appearance.

  • Dr Brian Kennedy, PhD

    Scientific Advisor

    Dr. Kennedy is a Distinguished Professor in the National University of Singapore (NUS) Yong Loo Lin School of Medicine, Departments of Biochemistry and Physiology. He is the Director of the Healthy Longevity Translational Research Programme in NUS and Director of the Centre For Healthy Longevity, National University Health System (NUHS). Prior to this, he was the President and CEO of the Buck Institute for Research on Aging and he maintained a professorship there through 2020. He served as the Co-Editor-In-Chief at the journal Aging Cell from 2011 to 2021.

    Dr. Kennedy is widely recognized for his contributions in the biology of aging and as a visionary committed to translating research discoveries into new ways to delay, detect and prevent human aging and its associated diseases. With a plethora of widely-cited research papers on aging and longevity under his belt, he is regarded as an expert in the science of gerontology.

  • Dr Stephen Lim

    Chief Pharmacist

    Dr Stephen Lim is an Adjunct Professor in the School of Pharmacy at Curtin University and has more than 35 years experience in the hospital and commercial pharmacy sectors. His interest is mainly in research, drug safety and drug delivery, especially in the area of needle-less systems.

    Dr Lim is also an expert in drug storage and extending the shelf-life of medication. He completed his Master thesis by looking at drug stability in the frozen state and has shown that intranasal fentanyl delivery is as effective as intravenous fentanyl.

    Dr Lim obtained a Bachelor of Pharmacy (with distinctions), a Master of Pharmacy and a Ph.D. in Pharmacy in novel, drug delivery system from Curtin University.

  • Dr Iain Cook

    Chief Scientist

    Dr Iain Cook has more than 30 years of experience in the analysis of complex pharmaceutical and biological samples, with a background in pharmaceutical, veterinary, industrial and agrichemical industries.

    Prior to his appointment as Chief Scientist, Dr Cook was the director of Chemical Analysis Pty Ltd. He also served as analytical chemist at ICI/Orica, where he specialised in nuclear magnetic resonance and led its Spectroscopy Group (NMR/FTIR/SEM-EDXA/NIR), and at PROBE Analytical thereafter.

    Dr Cook obtained his Doctor of Philosophy in Nuclear Magnetic Resonance and Synthetic Organic Chemistry from La Trobe University.

  • Dr Janakan Krishnarajah

    Chief Medical Officer

    Dr Janakan Krishnarajah is the Chief Operating and Medical Officer of iX Biopharma, parent company of Entity Health. In his capacity, he is responsible for iX Biopharma’s pharmaceutical and nutraceutical product development, including the design and implementation of clinical trial programmes. He also oversees the operations of the Group’s wholly owned certified GMP manufacturing facility in Australia.

    Dr Krishnarajah was formerly the CEO and Medical Director of Linear Clinical Research Ltd, a leading Australian early phase clinical trials facility. He has extensive experience in phase I-IV clinical trials and has acted as Principal or Co-Investigator in over 100 Phase I/II clinical trials.

    Dr. Krishnarajah graduated with a Bachelor of Medicine, Bachelor of Surgery (Hons) from The University of Western Australia. He is a Fellow of the Royal Australasian College of Physicians and Specialist in Clinical Pharmacology and Internal Medicine previously having worked as a Consultant Physician in Western Australia. He is also a member of Longevity Docs, an exclusive community dedicated to physicians pioneering precision and evidence-based practices in longevity medicine.