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Glutathione protects & repairs so you can glow from within


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Glutathione is the master of all antioxidants

 

It is the body’s ultimate defense against environmental stressors & ingested drugs and toxins

Glutathione, a powerful antioxidant produced naturally by all cells, especially the liver, is composed of three amino acids: glutamine, cysteine, and glycine. It plays a crucial role in protecting cells from damage caused by harmful free radicals.

Key Benefits of Glutathione include:

Cellular protection

Neutralizes harmful free radicals to safeguard cellular health and DNA integrity.

Detoxification

Helps the liver eliminate toxins and pollutants from the body.

Immune system support

Enhances immune cell function and regulates inflammation.

Viral defense

Protects against viral illnesses. Regenerates other antioxidants like vitamins C and E within the body.

Harmful free radicals damage DNA &
accelerates aging & disease

Glutathione neutralizes free radicals and
shields the body from oxidative stress

As we age, glutathione production progressively declines, resulting in increased oxidative stress and damage to cells and tissues.

This oxidative stress is believed to be a major contributor to the aging process and many age-related diseases.

Increasing glutathione levels can help to protect cells and tissues from oxidative damage.

 

Reveal healthy, youthful skin with the power of glutathione

 

Overcoming the challenges of Glutathione delivery with WaferiX

 

Clinically proven to increase skin elasticity, smoothness and luminosity*

Statistically significant positive results were observed for skin lightness, skin gloss, skin elasticity, eye wrinkles, and skin roughness. All these parameters showed positive therapeutic results within 14 days of therapy with high positive responder rates.

 
226Increase in skin elasticity
60Increase in skin luminosity & gloss
71Increase in skin smoothness
51Reduce eye wrinkles & fine lines

*Results within 8 weeks based on a clinical trial of 34 female participants with signs of skin ageing, evaluated objectively using skin measurement instruments. Results may vary.

 
References
  1. G. Gandhi et al. The master antioxidant – Beyond skin lightening agent. Pigment International, 2021, 8(3):141–152.
  2. R.V. Sekhar et al. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. American Journal of Clinical Nutrition, 2011, 94:847–853.
  3. S. Weschawalit et al. Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology, 2017, 10:147–153.
  4. R. Prussick et al. Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study. Journal of Clinical and Aesthetic Dermatology, 2013, 6(10):23–26.
  5. W. Droge et al. Glutathione and immune function. Proceedings of the Nutrition Society, 2000, 59:595–600.
  6. W. Dilokthornsakul et al. The clinical effect of glutathione on skin color and other related skin conditions: A systematic review. Journal of Cosmetic Dermatology, 2019, 18:728–737.
  7. E.M. Jeong et al. Real-Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function. Stem Cell Reports, 2018, 10:600–614.
  8. Honda et al. Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: An open-label, single-arm, multicenter, pilot study. BMC Gastroenterology, 2017, 17:96.
  9. B. Sido et al. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut, 1998, 42:485–492.
  10. J. Martensson et al. Glutathione is required for intestinal function. Proceedings of the National Academy of Sciences (PNAS), 1990, 87:1715–1719.
 
  • NAD powers DNA repair through PARP activation

    Another critical function that NAD powers is DNA repair. Every day, our DNA faces constant damage from what we eat, how we live, and exposure to harmful toxins and even UV radiation from the sun. If left unrepaired, it can lead to mutations, malfunctions and even dreaded diseases like cancer. To combat this, the body uses PARP proteins to repair the damaged DNA.

    PARPs need NAD to function.

  • NAD regulates the genes of aging and is known as the molecule of youth

    NAD is critical for the function of sirtuins, the “longevity proteins”. Sirtuins are a family of seven proteins linked to longevity and considered pivotal regulators of lifespan and healthspan through their involvement in fundamental biological processes.

    It plays a crucial role in the Krebs cycle, which is a series of biochemical reactions to release energy from nutrients like carbohydarates, fats and proteins. This takes place in the mitochondria, often referred to as the “powerhouse” of our cells. This cycle is essential for energy production, generating ATP, the primary energy currency of the cell.

    ATP is vital for maintaining cellular functions, facilitating biological processes, and supporting critical muscle functions, including breathing and the heartbeat.

    Sirtuins contribute to longevity by:

    • • Enhancing DNA repair and reducing damage, promoting cellular health
    • • Regulating metabolism, especially in response to caloric restriction, which is known to extend lifespan
    • • Reducing inflammation, thereby improving health and potentially extending lifespan
  • NAD powers the mitochondria, the powerhouse of the cells

    Naturally produced in the body, NAD+ is the oxidized form of nicotinamide adenine dinucleotide. It is a coenzyme found in all living cells and exists in the body as a redox pair.

    NAD is a molecule involved in critical biological processes such as cellular energy and cellular repair that make life possible.

  • Glutathione supports liver detoxification and health

    Glutathione is essential for liver health. The liver is constantly exposed to toxins and undergoes metabolic processes that generate harmful free radicals. Glutathione’s antioxidant properties protect liver cells from damage and supports the liver’s detoxification processes.

    In addition, glutathione regulates liver inflammation. By reducing chronic inflammation, it lowers the risk of liver diseases, such as fatty liver disease, and supports healthy liver function.

    Glutathione also aids in fat processing and elimination by supporting bile production, which is necessary for fat digestion and absorption. Through enhanced fat metabolism, glutathione further promotes overall liver health.

  • Glutathione enhances immunity and fights viral infections

    Glutathione is essential for immune health, supporting the function of T cells, B cells, and macrophages. Some studies also suggest that it may help disrupt the replication of certain viruses.

    As we age, glutathione also helps address skin discoloration by inhibiting tyrosinase, the enzyme responsible for melanin production, which reduces dark spots and uneven pigmentation. It also offers protection against UV radiation, helping to prevent photoaging.

  • Glutathione protects against premature skin aging

    Free radicals generated by environmental factors such as UV radiation, pollution, and toxins damage skin cells, leading to premature aging, wrinkles, and other skin problems.

    By neutralizing free radicals, glutathione protects the skin’s delicate balance and prevents premature aging.

    Glutathione plays a crucial role in managing inflammation, which is key in skin conditions such as acne, eczema, and psoriasis. By modulating the inflammatory response, it reduces redness, irritation, and other symptoms while supporting a healthy skin barrier for a youthful, radiant complexion. This contributes to improved skin texture, tone, and an overall vibrant appearance.

  • Dr Brian Kennedy, PhD

    Scientific Advisor

    Dr. Kennedy is a Distinguished Professor in the National University of Singapore (NUS) Yong Loo Lin School of Medicine, Departments of Biochemistry and Physiology. He is the Director of the Healthy Longevity Translational Research Programme in NUS and Director of the Centre For Healthy Longevity, National University Health System (NUHS). Prior to this, he was the President and CEO of the Buck Institute for Research on Aging and he maintained a professorship there through 2020. He served as the Co-Editor-In-Chief at the journal Aging Cell from 2011 to 2021.

    Dr. Kennedy is widely recognized for his contributions in the biology of aging and as a visionary committed to translating research discoveries into new ways to delay, detect and prevent human aging and its associated diseases. With a plethora of widely-cited research papers on aging and longevity under his belt, he is regarded as an expert in the science of gerontology.

  • Dr Stephen Lim

    Chief Pharmacist

    Dr Stephen Lim is an Adjunct Professor in the School of Pharmacy at Curtin University and has more than 35 years experience in the hospital and commercial pharmacy sectors. His interest is mainly in research, drug safety and drug delivery, especially in the area of needle-less systems.

    Dr Lim is also an expert in drug storage and extending the shelf-life of medication. He completed his Master thesis by looking at drug stability in the frozen state and has shown that intranasal fentanyl delivery is as effective as intravenous fentanyl.

    Dr Lim obtained a Bachelor of Pharmacy (with distinctions), a Master of Pharmacy and a Ph.D. in Pharmacy in novel, drug delivery system from Curtin University.

  • Dr Iain Cook

    Chief Scientist

    Dr Iain Cook has more than 30 years of experience in the analysis of complex pharmaceutical and biological samples, with a background in pharmaceutical, veterinary, industrial and agrichemical industries.

    Prior to his appointment as Chief Scientist, Dr Cook was the director of Chemical Analysis Pty Ltd. He also served as analytical chemist at ICI/Orica, where he specialised in nuclear magnetic resonance and led its Spectroscopy Group (NMR/FTIR/SEM-EDXA/NIR), and at PROBE Analytical thereafter.

    Dr Cook obtained his Doctor of Philosophy in Nuclear Magnetic Resonance and Synthetic Organic Chemistry from La Trobe University.

  • Dr Janakan Krishnarajah

    Chief Medical Officer

    Dr Janakan Krishnarajah is the Chief Operating and Medical Officer of iX Biopharma, parent company of Entity Health. In his capacity, he is responsible for iX Biopharma’s pharmaceutical and nutraceutical product development, including the design and implementation of clinical trial programmes. He also oversees the operations of the Group’s wholly owned certified GMP manufacturing facility in Australia.

    Dr Krishnarajah was formerly the CEO and Medical Director of Linear Clinical Research Ltd, a leading Australian early phase clinical trials facility. He has extensive experience in phase I-IV clinical trials and has acted as Principal or Co-Investigator in over 100 Phase I/II clinical trials.

    Dr. Krishnarajah graduated with a Bachelor of Medicine, Bachelor of Surgery (Hons) from The University of Western Australia. He is a Fellow of the Royal Australasian College of Physicians and Specialist in Clinical Pharmacology and Internal Medicine previously having worked as a Consultant Physician in Western Australia. He is also a member of Longevity Docs, an exclusive community dedicated to physicians pioneering precision and evidence-based practices in longevity medicine.